Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
This antibody is predicted to react with bovine, canine, feline, mouse, porcine and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000.
Serotonin (5-hydroxytryptamine, 5-HT), originally discovered as a serum factor plays important roles in regulating diverse biological processes in central and peripheral nervous systems, cardiovascular systems, and gastrointestinal systems. Molecular cloning studies have identified 5 receptors belonging to the 5-HT1 subtypes. These receptors are negatively coupled to adenylyl cyclase. Radioligand binding studies suggest the presence of 5-HT1B (formerly known as 5-HT1DbR) sites in substantia nigra, dorsal subiculum, globus pallidus, and superior collicum. In situ hybridization studies show abundance of 5-HT1BR mRNA in CA1 pyramidal cells of hippocampus, Purkinje cells of cerebellum, olfactory tubercle, subthalamic nucleus and somewhat lower levels in the caudate-putamen, cortical areas, thalamic and hypothalamic nuclei.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 5-HT-1B; 5-HT-1D-beta; 5-HT1B receptor; 5-HT<1B> receptor; 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled; 5-hydroxytryptamine receptor 1B; 5HT1B Receptor; S12; Serotonin 1D beta receptor; Serotonin receptor 1B
Gene Aliases: 5-HT-1B; 5-HT-1D-beta; 5-HT1B; 5-HT1DB; 5ht1b; HTR1B; HTR1D2; HTR1DB; S12
UniProt ID: (Human) P28222, (Mouse) P28334
Entrez Gene ID: (Human) 3351, (Mouse) 15551
Molecular Function:
G-protein coupled receptor
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support