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Product Details
14162-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HVCN1 Fusion Protein Ag5350 (1-103 aa encoded by BC032672)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MATWDEKAV TRRAKVAPAE RMSKFLRHFT VVGDDYHAWN INYKKWENEE EEEEEEQPPP TPVSGEEGRA AAPDVAPAPG PAPRAPLDFR GMLRKLFSSH RFQV (1-103 aa encoded by BC032672)
Target Information
HVCN1 (hydrogen voltage-gated channel 1), a voltage gated proton channel protein that is highly expressed in immune tissues, mediates the proton conductances required by phagocytic leukocytes for the oxidative burst that underlies microbial killing. HVCN1 moderates the voltage-dependent proton permeability of excitable membranes by allowing the flow of protons in accordance to their electrochemical gradient. HVCN1 is sensitive to zinc ions, and can be inhibited by them. HVCN1 may represent a new therapeutic target for B cell malignancies on continued signaling via the B cell antigen receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: HV1; Hydrogen voltage-gated channel 1; Voltage sensor domain-only protein; Voltage-gated hydrogen channel 1
Gene Aliases: HV1; HVCN1; UNQ578/PRO1140; VSOP
UniProt ID: (Human) Q96D96
Entrez Gene ID: (Human) 84329
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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