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Histamine H3 Receptor (HRH3) Antibody (AHR-003-200UL) in IHC (F)
Expression of Histamine H3receptor in rat cerebellum - Immunohistochemical staining of rat brain frozen sections with Anti-Histamine H3Receptor (HRH3) Antibody (#AHR-003), (1:100), (green). A.H3R is particularly expressed in dendrites of Purkinje cells (arrows).B. Staining with mouse Anti-parvalbumin (red) detected Purkinje cells and interneurons in the molecular layer. C. Merge of the two images demonstrat... View More
Product Details
AHR-003-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)RTRLRLDGGREAGPE, corresponding to amino acids 228-242 of rat HRH3, 3rd intracellular loop
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
H3 Histamine Receptor regulates the release of the neurotransmitters norepinephrine and somatostatin. In histamine-containing neurons of the brain, the H3 receptor acts as a presynaptic autoreceptor, while in nonhistamine-containing neurons, in both the central and peripheral nervous systems, it acts as a presynaptic heteroreceptor. Multiple isoforms of H3 receptors are produced by alternative splicing. Histamine H3 receptor has been reported primarily in brain. ESTs have been isolated from brain (normal and cancer), breast cancer, colon cancer, and retinoblastoma libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: H3R; HH3R; Histamine H3 receptor; histamine receptor
Gene Aliases: AW049250; H3R; HH3R; Hrh3
UniProt ID: (Rat) Q9QYN8, (Mouse) P58406
Entrez Gene ID: (Rat) 85268, (Mouse) 99296
regulation of neurotransmitter levels
G-protein coupled receptor signaling pathway
negative regulation of adenylate cyclase activity
positive regulation of cytosolic calcium ion concentration
brain development
learning
memory
negative regulation of glutamate secretion
negative regulation of gamma-aminobutyric acid secretion
regulation of norepinephrine secretion
negative regulation of serotonin secretion
response to organic cyclic compound
eating behavior
drinking behavior
negative regulation of blood pressure
positive regulation of epithelial cell proliferation
cognition
signal transduction
sensory perception of chemical stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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