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Product Details
RP-105260
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
LFKRRNVATAEEETEEEVMSDGGFHEAQISNM
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Unconjugated
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
PBS/1M urea, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (97%), Rat (97%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-84596. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
Recombination activating proteins RAG1 and RAG2 regulate and mediate VJ recombination, the process by which genes for immunoglobulins and T-cell receptors are generated. Several other ubiquitously expressed proteins are thought to be recruited in the recombination process. Among these are the genes affected in severe combined immune deficiency and genes involved in ds-DNA break repair. The protein encoded by this gene interacts with RAG1 and may play a role in VJ recombination. Two transcript variants, one protein-coding and the other not, have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: IMA2; Importin alpha 2; importin alpha 5; Importin alpha P1; importin subunit alpha-1; Importin subunit alpha-5; importin-alpha-S1; IPOA 1; IPOA1; Karyopherin A2; karyopherin alpha 1 (importin alpha 5); Karyopherin subunit alpha-1; KPNA2; NPI-1; Nucleoprotein interactor 1; RAG cohort 1; RAG cohort protein 2; RCH 1; RCH1; recombination activating gene cohort 2; SRP 1; SRP1 alpha; SRP1-beta
Gene Aliases: IPOA5; KPNA1; NPI-1; RCH2; SRP1
UniProt ID: (Human) P52294
Entrez Gene ID: (Human) 3836
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