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Immunogen sequence: GVYTERCAQG LRCLPRQDEE KPLHALLHGR GVCLNEKSYR EQVKIERDSR EHEEPTTSEM AEETYSPKIF RPKHTRISEL KAEAVKKDRR KKLTQSKFVG
Positive Samples: PC-3, BT-474, U-937, Mouse kidney, Mouse skeletal muscle, Mouse lung, Mouse heart
The insulin-like growth factor-binding proteins, or IGFBPs, are a family of homologous proteins that have co-evolved with the IGFs. They serve not only as shuttle molecules for the soluble IGFs, but also confer a level of regulation to the IGF signaling system. Physical association of the IGFBPs with IGF influences the bio-availability of the growth factors, as well as their concentration and distribution in the extracellular environment. In addition, the IGFBPs appear to have biological activity independent of the IGFs. Seven IGFBPs have thus far been described, each differing in their tissue distribution, half-lives and modulation of IGF interactions with their receptors. For instance, IGFBP1 is negatively regulated by insulin production. The IGFBP1 gene is expressed at a high level during fetal liver development and in response to nutritional changes and diabetes. It has been suggested that IGFBP2 functions as chaperone, escorting IGFs to their target tissues. It is expressed in several human tissues including fetal eye and fetal brain. IGFBP3 is the most abundant IGFBP and is complexed with roughly 80% of the serum IGFs. Both IGFBP3 and IGFBP4 are released by dermal fibroblasts in response to incision injury. IGFBP5 is secreted by myoblasts and may play a key role in muscle differentiation.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: IBP 5; IBP-5; IGF BP5; IGF-binding protein 5; IGFBP; IGFBP 5; IGFBP-5; Insulin like growth factor binding protein; insulin-like growth factor binding protein 5; Insulin-like growth factor-binding protein 5
Gene Aliases: AI256729; AW208790; IBP5; IGFBP-5; IGFBP-5P; IGFBP5
UniProt ID: (Human) P24593, (Mouse) Q07079
Entrez Gene ID: (Human) 3488, (Mouse) 16011
Molecular Function:
protease inhibitor
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