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IGF-BPs control the distribution, function and activity of IGFs in various cell tissues and body fluids. IGF-BP6, which specifically inhibits IGF-II actions, is produced by bone cells and is the major IGF-BP present in cerebrospinal fluid. IGF-BP6 has been shown to inhibit IGF-II-dependent cancers such as neuroblastoma, colon cancer and rhabdomyosarcoma.
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Protein Aliases: IBP-6; IGF binding protein 6; IGF-binding protein 6; IGFBP; IGFBP-6; Insulin like growth factor binding protein; insulin-like growth factor binding protein 6; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 6 PRECURSOR (IGFBP-6) (IBP-6) (IGF-BINDING PROTEIN 6); Insulin-like growth factor-binding protein 6
Gene Aliases: IBP6; IGF-BP6; IGFBP-6; IGFBP6; RBP6A
UniProt ID: (Human) P24592, (Rat) P35572, (Mouse) P47880
Entrez Gene ID: (Human) 3489, (Rat) 25641, (Mouse) 16012
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