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            • Primary Antibodies ›
            • IKK beta Antibodies
            The product (cat # 40907) that you're looking for has been discontinued and replaced with MA5-16162. The product (cat # 40907) that you're looking for has been discontinued. Please contact Technical Support with any questions.

            Active Motif

            IKK beta Monoclonal Antibody (10A9B6)

            1 Reference
            View all (49) IKK beta antibodies
            Datasheet
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            Datasheet
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            Cite IKK beta Monoclonal Antibody (10A9B6)

            • Antibody Testing Data (1)
            Application
            IKK beta Antibody in Western Blot (WB)
            Group 53 Created with Sketch.

            FIGURE: 1 / 1

            IKK beta Antibody (40907) in WB

            IKKbeta mAb (Clone 10A9B6) tested by Western blot. Immunoprecipitation of IKKbeta. 2 µg of IKKbeta mAb (Clone 10A9B6) was used to immunoprecipitate IKKbeta from 1 x 106 cells. The immunoprecipitated protein was detected by Western blotting using the same antibody. The IKKbeta protein detected was ~87 kDa in size.
            View Product

            IKK beta Antibody in Western Blot (WB)

            Product Details

            40907

            Applications
            Tested Dilution
            Publications

            Western Blot (WB)

            1-2 µg/mL
            View 1 publication 1 publication

            Immunoprecipitation (IP)

            2 µg
            -
            Product Specifications

            Host/Isotype

            Mouse / IgG1

            Class

            Monoclonal

            Type

            Antibody

            Clone

            10A9B6

            Immunogen

            This Ikk beta antibody was raised against a 6xHis-Tag full-length protein corresponding to human Ikk beta.
            View immunogen

            Conjugate

            Unconjugated

            Form

            Liquid

            Concentration

            1 mg/mL

            Storage conditions

            -20°C, Avoid Freeze/Thaw Cycles

            Shipping conditions

            Ambient (domestic); Wet ice (international)

            RRID

            AB_2793430

            Target Information

            Phosphorylation of serine residues on the I-kappa-B proteins by IKK kinases, including IKBKB, marks them for destruction via the ubiquitination pathway, allowing activation of the NF-kappa-B complex. Inhibitor of nuclear factor kappa-B kinase subunit beta (IKK beta) is a serine kinase that plays an essential role in the NF-kaapa-B signaling pathway which is activated by mulitple stimuli such as inflammatory cytokines, bacterial, or viral products, DNA damages, or other cellular stresses. IKK beta acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Mutations affecting the IKK beta gene can result in Immunodeficiency 15 (IMD15).

            For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

            It has to be done as per old AB suggested Products section.
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            If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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