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IKZF1 Polyclonal Antibody

IKZF1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 4

IKZF1 Antibody (12016-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human lymphoma tissue slide using (Product # 12016-1-AP) (IKZF1 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

IKZF1 Antibody in Immunoprecipitation (IP)

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Product Details

12016-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2400

View 4 publications 4 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

IKZF1 Fusion Protein Ag2631 (1-303 aa encoded by BC018349)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MDADEGQDM SQVSGKESPP VSDTPDEGDE PMPIPEDLST TSGGQQSSKS DRVVASNVKV ETQSDEENGR ACEMNGEECA EDLRMLDASG EKMNGSHRDQ GSSALSGVGG IRLPNGKLKC DICGIICIGP NVLMVHKRSH TGERPFQCNQ CGASFTQKGN LLRHIKLHSG EKPFKCHLCN YACRRRDALT GHLRTHSVIK EETNHSEMAE DLCKIGSERS LVLDRLASNV AKRKSSMPQK FLGDKGLSDT PYDSSASYEK ENEMMKSHVM DQAINNAINY LGAESLRPLV QTPPGGSEVV PVIS (1-303 aa encoded by BC018349)

Target Information

DNA-binding protein IKAROS functions in the specification and the maturation of the T lymphocyte. It also interacts with a critical control element in the terminal deoxynucleotidyl transferase promoter as well as with the promoters for other genes expressed during early stages of B-cell and T-cell development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Discovery of novel BTK PROTACs with improved metabolic stability via linker rigidification strategy.

European journal of medicinal chemistry

Chen S,Chen Z,Lu L,Zhao Y,Zhou R,Xie Q,Shu Y,Lin J,Yu X,Wang Y

Wed Jul 05 00:00:00 EDT 2023

Discovery of potential novel CRBN modulators by virtual screening and bioassay.

European journal of medicinal chemistry

Xiong F,Kong L,Chen L,Xue M,Cao F,Zhang S,Li H,Yan H,Li Y,Zuo Z

Sun Jun 05 00:00:00 EDT 2022

Discovery of potential novel CRBN modulators by virtual screening and bioassay.

European journal of medicinal chemistry

Xiong F,Kong L,Chen L,Xue M,Cao F,Zhang S,Li H,Yan H,Li Y,Zuo Z

Sun Jun 05 00:00:00 EDT 2022

Mechanistic Basis for In Vivo Therapeutic Efficacy of CK2 Inhibitor CX-4945 in Acute Myeloid Leukemia.

Cancers

Klink M,Rahman MA,Song C,Dhanyamraju PK,Ehudin M,Ding Y,Steffens S,Bhadauria P,Iyer S,Aliaga C,Desai D,Huang S,Claxton D,Sharma A,Gowda C

Fri Mar 05 00:00:00 EST 2021

Expression of CRBN, IKZF1, and IKZF3 does not predict lenalidomide sensitivity and mutations in the cereblon pathway are infrequent in multiple myeloma.

Leukemia & lymphoma

Dimopoulos K,Fibiger Munch-Petersen H,Winther Eskelund C,Dissing Sjö L,Ralfkiaer E,Gimsing P,Grønbaek K

Tue Jan 01 00:00:00 EST 2019

Expression of CRBN, IKZF1, and IKZF3 does not predict lenalidomide sensitivity and mutations in the cereblon pathway are infrequent in multiple myeloma.

Leukemia & lymphoma

Dimopoulos K,Fibiger Munch-Petersen H,Winther Eskelund C,Dissing Sjö L,Ralfkiaer E,Gimsing P,Grønbaek K

Tue Jan 01 00:00:00 EST 2019

Dual inhibition of DNMTs and EZH2 can overcome both intrinsic and acquired resistance of myeloma cells to IMiDs in a cereblon-independent manner.

Molecular oncology

Dimopoulos K,Søgaard Helbo A,Fibiger Munch-Petersen H,Sjö L,Christensen J,Sommer Kristensen L,Asmar F,Hermansen NEU,O'Connel C,Gimsing P,Liang G,Grønbaek K

Thu Feb 01 00:00:00 EST 2018

Dual inhibition of DNMTs and EZH2 can overcome both intrinsic and acquired resistance of myeloma cells to IMiDs in a cereblon-independent manner.

Molecular oncology

Dimopoulos K,Søgaard Helbo A,Fibiger Munch-Petersen H,Sjö L,Christensen J,Sommer Kristensen L,Asmar F,Hermansen NEU,O'Connel C,Gimsing P,Liang G,Grønbaek K

Thu Feb 01 00:00:00 EST 2018

A Novel Regulatory Mechanism of Smooth Muscle α-Actin Expression by NRG-1/circACTA2/miR-548f-5p Axis.

Circulation research

Sun Y,Yang Z,Zheng B,Zhang XH,Zhang ML,Zhao XS,Zhao HY,Suzuki T,Wen JK

Fri Sep 01 00:00:00 EDT 2017

A Novel Regulatory Mechanism of Smooth Muscle α-Actin Expression by NRG-1/circACTA2/miR-548f-5p Axis.

Circulation research

Sun Y,Yang Z,Zheng B,Zhang XH,Zhang ML,Zhao XS,Zhao HY,Suzuki T,Wen JK

Fri Sep 01 00:00:00 EDT 2017

Bioinformatics

Protein Aliases: CLL-associated antigen KW-6; DNA-binding protein Ikaros; hIk-1; IKAROS family zinc finger 1 (Ikaros); Ikaros family zinc finger protein 1; Lymphoid transcription factor LyF-1; protein phosphatase 1, regulatory subunit 92; zinc finger protein, subfamily 1A, 1 (Ikaros)

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Gene Aliases: 5832432G11Rik; CVID13; hlk-1; Hs.54452; IK1; IKAROS; IKZF1; LyF-1; LYF1; mKIAA4227; PPP1R92; PRO0758; RGD1562979; Zfpn1a1; ZNFN1A1

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UniProt ID: (Human) Q13422

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Entrez Gene ID: (Human) 10320, (Mouse) 22778, (Rat) 305501

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Function(s)

DNA binding transcription factor activity, sequence-specific DNA binding protein binding transcription regulatory region DNA binding metal ion binding RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding sequence-specific DNA binding protein heterodimerization activity C2H2 zinc finger transcription factor

Process(es)

negative regulation of transcription from RNA polymerase II promoter transcription, DNA-templated cell cycle mesoderm development covalent chromatin modification lymphocyte differentiation erythrocyte differentiation negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter natural killer cell differentiation regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter hemopoiesis B cell differentiation T cell differentiation forebrain development positive regulation of multicellular organism growth positive regulation of B cell differentiation positive regulation of neutrophil differentiation positive regulation of transcription, DNA-templated lymph node development thymus development Peyer's patch development gland development positive regulation of NK T cell differentiation retina development in camera-type eye

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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IKZF1 Polyclonal Antibody

IKZF1 Antibody (12016-1-AP) in IHC (P)

Product Details

12016-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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