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Invitrogen
IL-6 Monoclonal Antibody (6B4 IGH 54), eBioscience™
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Application
FIGURE: 1 / 2
IL-6 Antibody (BMS178) in ELISA, Neu
Scientific reports 2016 -
Figure 7 Suppressed production of IL-6 and TNF-alpha in Arg-II -/- macrophages accounts for reduced lipogenesis in hepatocyte AML12 cells. The serum-starved (overnight) WT- or Arg-II -/- -BMM were incubated in the absence or presence of 100 ng/ml LPS for 8 hours, the conditioned medium (CM) was then collected. (A) IL-6 and TNF-alpha production in CM collected from WT- or Arg-II -/- -BMMs in the absence or p... View More
Product Details
BMS178
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Published species
Mouse
Host/Isotype
Rat
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
6B4 IGH 54
Immunogen
Rec. Mouse IL-6
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS
Contains
no preservative
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10597433
Product Specific Information
Description: Clone 6B4 IGH 54 can be used to neutralise the activity of 50pg/mL of recombinant mouse IL-6 by >95% in a functional assay.
Applications Tested: ELISA, Functional Studies (Blocking).
Purity: >95%.
Target Information
IL-6 is a gene that encodes a cytokine that plays a role in inflammation and the maturation of B cells. The protein produced by this gene is an endogenous pyrogen that can induce fever in people with autoimmune diseases or infections. The gene is primarily expressed at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). Diseases associated with IL6 include Kaposi Sarcoma and Rheumatoid Arthritis, Systemic Juvenile.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: B-cell hybridoma growth factor; H-IL-6; IL-6; ILN; Interleukin; Interleukin HP-1; Interleukin-6; Interleukin6; M-IL-6; R-IL-6
Gene Aliases: Il-6; Il6
UniProt ID: (Mouse) P08505
Entrez Gene ID: (Mouse) 16193
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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