Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
SPPL2B is a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: IMP-4; Intramembrane protease 4; MGC111084; Presenilin homologous protein 4; Presenilin-like protein 1; protein SPP-like 2B; protein SPPL2b; PSH4; Signal peptide peptidase-like 2B; SPP-like 2B
Gene Aliases: 3110056O03Rik; AW550292; IMP-4; IMP4; KIAA1532; PSH4; PSL1; RGD1308556; SPPL2B
UniProt ID: (Human) Q8TCT7, (Rat) Q5PQL3, (Mouse) Q3TD49
Entrez Gene ID: (Human) 56928, (Rat) 362828, (Mouse) 73218
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support