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            Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

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            • Primary Antibodies ›
            • INPP5E Antibodies

            Proteintech

            INPP5E Polyclonal Antibody

            50 References
            View all (11) INPP5E antibodies
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            Cite INPP5E Polyclonal Antibody

            • Antibody Testing Data (23)
            Application
            INPP5E Antibody in Immunocytochemistry (ICC/IF)
            Group 53 Created with Sketch.

            FIGURE: 1 / 23

            INPP5E Antibody (17797-1-AP) in ICC/IF

            IF result of ciliary INPP5E in human hTERT-RPE1 cell: Upper is from control siRNA transfected cells and bottom is from INPP5E siRNA transfected cells. 17797-1-AP specifically recognizes the ciliary INPP5E (From Dr.Seongjin Seo).
            View Product

            INPP5E Antibody in Immunocytochemistry (ICC/IF)
            INPP5E Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            INPP5E Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            INPP5E Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            INPP5E Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            INPP5E Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            INPP5E Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            INPP5E Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            INPP5E Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            INPP5E Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            INPP5E Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            INPP5E Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            INPP5E Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            INPP5E Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            INPP5E Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            INPP5E Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            INPP5E Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            INPP5E Antibody in Western Blot (WB)
            INPP5E Antibody in Western Blot (WB)
            INPP5E Antibody in Western Blot (WB)
            INPP5E Antibody in Western Blot (WB)
            INPP5E Antibody in Western Blot (WB)
            INPP5E Antibody in Immunoprecipitation (IP)

            Product Details

            17797-1-AP

            Applications
            Tested Dilution
            Publications

            Western Blot (WB)

            1:500-1:2,000
            View 14 publications 14 publications

            Immunohistochemistry (IHC)

            -
            View 1 publication 1 publication

            Immunohistochemistry (Paraffin) (IHC (P))

            1:20-1:200
            -

            Immunocytochemistry (ICC/IF)

            1:20-1:200
            View 31 publications 31 publications

            Immunoprecipitation (IP)

            0.5-4.0 µg
            View 1 publication 1 publication

            Miscellaneous PubMed (Misc)

            -
            View 1 publication 1 publication

            Not applicable (N/A)

            -
            View 2 publications 2 publications
            Product Specifications

            Species Reactivity

            Human, Mouse, Rat

            Published species

            Human, Mouse, Zebrafish

            Host/Isotype

            Rabbit / IgG

            Class

            Polyclonal

            Type

            Antibody

            Immunogen

            INPP5E Fusion Protein Ag11959 (1-350 aa encoded by BC028032)
            View immunogen

            Conjugate

            Unconjugated

            Form

            Liquid

            Concentration

            0.36 mg/mL

            Purification

            Antigen affinity chromatography

            Storage buffer

            PBS, pH 7.3, with 50% glycerol

            Contains

            0.02% sodium azide

            Storage conditions

            -20°C

            Shipping conditions

            Wet ice (domestic); Dry ice (international)

            Product Specific Information

            Immunogen sequence: MPSKAENLR PSEPAPQPPE GRTLQGQLPG APPAQRAGSP PDAPGSESPA LACSTPATPS GEDPPARAAP IAPRPPARPR LERALSLDDK GWRRRRFRGS QEDLEARNGT SPSRGSVQSE GPGAPAHSCS PPCLSTSLQE IPKSRGVLSS ERGSPSSGGN PLSGVASSSP NLPHRDAAVA GSSPRLPSLL PPRPPPALSL DIASDSLRTA NKVDSDLADY KLRAQPLLVR AHSSLGPGRP RSPLACDDCS LRSAKSSFSL LAPIRSKDVR SRSYLEGSLL ASGALLGADE LARYFPDRNV ALFVATWNMQ GQKELPPSLD EFLLPAEADY AQDLYVIGVQ EGCSDRREWE T (1-350 aa encoded by BC028032)

            Target Information

            INPP5E (inositol polyphosphate 5-phosphatase), also known as phosphatidylinositol polyphosphate 5-phosphatase type IV, is a 644 amino acid peripheral membrane protein associated with Golgi stacks. Belonging to the inositol-1, 4, 5-trisphosphate 5-phosphatase type IV family, INPP5E converts phosphatidylinositol-3, 4, 5-triphosphate (PtdIns 3, 4, 5-P3) to PtdIns-P2. While inactive towards water soluble inositol phosphates, the activity of INPP5E is specific for lipid substrates. INPP5E becomes phosphorylated upon DNA damage and is expressed in brain, heart, pancreas, testis and spleen. Defects in INPP5E are the cause of Joubert syndrome type 1 (JBTS1), a disorder presenting with cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. In addition, mutations in the INPP5E gene may lead to mental retardation-truncal obesity-retinal dystrophy-micropenis (MORMS), an autosomal recessive disorder characterized by moderate mental retardation, truncal obesity, congenital non-progressive retinal dystrophy, and micropenis in males.

            For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

            Bioinformatics

            Protein Aliases: 5-phosphatase that induces arborization; 72 kDa inositol polyphosphate 5-phosphatase; inositol polyphosphate 5-phosphatase; Inositol polyphosphate-5-phosphatase E; inositol polyphosphate-5-phosphatase, 72 kDa; Pharbin; Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; Phosphatidylinositol polyphosphate 5-phosphatase type IV; Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase; phosphatidylinositol-4,5-bisphosphate 5-phosphatase

            View more View less

            Gene Aliases: 1200002L24Rik; 72kDa; CORS1; CPD4; INPP5E; JBTS1; mKIAA0123; MORMS; PPI5PIV

            View more View less

            UniProt ID: (Human) Q9NRR6, (Rat) Q9WVR1, (Mouse) Q9JII1

            View more View less

            Entrez Gene ID: (Human) 56623, (Rat) 114089, (Mouse) 64436

            View more View less

            Function(s)

            phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity inositol-polyphosphate 5-phosphatase activity hydrolase activity hydrolase phosphatase metabolite interconversion enzyme

            Process(es)

            phosphatidylinositol biosynthetic process biological_process positive regulation of neuron projection development inositol phosphate dephosphorylation phosphatidylinositol dephosphorylation phosphatidylinositol metabolic process lipid metabolic process dephosphorylation
            It has to be done as per old AB suggested Products section.
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