Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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Immunogen sequence: GGQGAGNTGG LEPVHPASLP DSSLATSAPL CCTLCHERLE DTHFVQCPSV PSHKFCFPCS RQSIKQQGAS G
The nuclear factor of activated T-cells (NFAT) transcription complex is required for the expression of a group of proteins that collectively regulate the immune response. Four NFAT proteins, encoded on separate genes and expressed as several splice variants, have been described: NFAT1 (also known as NFATp or NFATc2), NFAT2 (NFATc or NFATc1), NFAT3, and NFAT4 (NFATx or NFATc3). These proteins show a low level of sequence similarity with the Dorsal/Rel/NFkB family of transcription factors. Another NFAT-related protein termed NFAT5 differs from isoforms 1-4 in that it lacks many of the Fos/Jun contact sites observed in its predecessors and its subcellular localization is not calcineurin-dependent.
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For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Interferon regulatory factor 2-binding protein 2; IRF-2-binding protein 2
Gene Aliases: E130305N23Rik; IRF-2BP2; IRF2BP2
UniProt ID: (Human) Q7Z5L9, (Mouse) E9Q1P8
Entrez Gene ID: (Human) 359948, (Mouse) 270110
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