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Proteintech

IRG1 Polyclonal Antibody

View all (3) IRG1 antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (1)

Application

FIGURE: 1 / 1

IRG1 Antibody (28436-1-AP) in WB

IFN gamma+LPS treated THP-1 cells were subjected to SDS PAGE followed by western blot with 28436-1-AP (IRG1 antibody) at dilution of 1:1,000 incubated at room temperature for 1.5 hours.

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Product Details

28436-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

ELISA (ELISA)

Assay-dependent

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein

View immunogen

Conjugate

Unconjugated

Form

Liquid

Purification

Antigen affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: DAAASVRKHL VAERALLPTD YIKRIVLRIP NVQYVNRPFP VSEHEARHSF QYVACAMLLD GGITVPSFHE CQINRPQVRE LLSKVELEYP PDNLPSFNIL YCEISVTLKD GATFTDRSDT FYGHWRKPLS QEDLEEKFRA NASKMLSWDT VESLIKIVKN LEDLEDCSVL TTLLKGPSPP EVASNSPACN NSITNLS

Target Information

Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)- mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; IRG1- mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Aconitate decarboxylase; Aconitate decarboxylase 1; CAD; Cis-aconitate decarboxylase; Cis-aconitic acid decarboxylase; Immune-responsive gene 1 protein; immune-responsive gene 1 protein homolog; immunoresponsive 1 homolog

Gene Aliases: ACOD1; AI323667; CAD; IRG1

UniProt ID: (Human) A6NK06, (Mouse) P54987

Entrez Gene ID: (Human) 730249, (Mouse) 16365

Function(s)

Process(es)

positive regulation of antimicrobial humoral response defense response inflammatory response embryo implantation metabolic process negative regulation of NF-kappaB transcription factor activity negative regulation of type I interferon production negative regulation of toll-like receptor 2 signaling pathway negative regulation of toll-like receptor 4 signaling pathway cellular response to interferon-beta negative regulation of innate immune response negative regulation of inflammatory response cellular response to molecule of bacterial origin cellular response to lipopolysaccharide cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to progesterone stimulus tolerance induction to lipopolysaccharide positive regulation of reactive oxygen species metabolic process immune system process propionate catabolic process response to lipopolysaccharide innate immune response

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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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