Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Recommended positive controls: A549.
Predicted reactivity: Mouse (90%), Rat (90%), Chimpanzee (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Integrin-alpha FG-GAP repeat-containing protein 2; KICSTOR complex protein ITFG2
Gene Aliases: ITFG2; MDS028
UniProt ID: (Human) Q969R8
Entrez Gene ID: (Human) 55846
Molecular Function:
cell adhesion molecule
integrin
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