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The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple proteins made up of a light chain (see MIM 176870) and a variable number of heavy chains (Salier et al., 1987 [PubMed 2446322]; Himmelfarb et al., 2004 [PubMed 14744536]).
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Protein Aliases: CYCSP39; HCP39; inter-alpha (globulin) inhibitor, H1 polypeptide; inter-alpha-inhibitor heavy chain 1; Inter-alpha-trypsin inhibitor complex component III; Inter-alpha-trypsin inhibitor heavy chain H1; ITI heavy chain H1; MGC126415; Serum-derived hyaluronan-associated protein; SHAP
Gene Aliases: H1P; IATIH; IGHEP1; Intin1; ITI-HC1; ITIH; Itih-1; ITIH1; SHAP
UniProt ID: (Human) P19827, (Mouse) Q61702
Entrez Gene ID: (Human) 3697, (Mouse) 16424, (Rat) 306251
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