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Application
FIGURE: 1 / 2
ITM2B Antibody (H00009445-B02P) in WB
Western Blot analysis of ITM2B expression in transfected 293T cell line (H00009445-T04) by ITM2B MaxPab polyclonal antibody.
Lane 1: ITM2B transfected lysate(29.26 KDa).
Lane 2: Non-transfected lysate.
Lane 1: ITM2B transfected lysate(29.26 KDa).
Lane 2: Non-transfected lysate.
Product Details
H00009445-B02P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ITM2B (NP_068839.1, 1 a.a. approximately 266 a.a) full-length human protein.
Conjugate
Unconjugated
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MVKVTFNSAL AQKEAKKDEP KSGEEALIIP PDAVAVDCKD PDDVVPVGQR RAWCWCMCFG LAFMLAGVIL GGAYLYKYFA LQPDDVYYCG IKYIKDDVIL NEPSADAPAA LYQTIEENIK IFEEEEVEFI SVPVPEFADS DPANIVHDFN KKLTAYLDLN LDKCYVIPLN TSIVMPPRNL LELLINIKAG TYLPQSYLIH EHMVITDRIE NIDHLGFFIY RLCHDKETYK LQRRETIKGI QKREASNCFA IRHFENKFAV ETLICS
Target Information
Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ABri/ADan amyloid peptide; Bri; BRICHOS domain containing 2B; imBRI2; Immature BRI2; Integral membrane protein 2B; OTTHUMP00000018394; Protein E25B; RP11-196P14.1; Transmembrane protein BRI
Gene Aliases: ABRI; BRI; BRI2; BRICD2B; E25B; E3-16; FBD; imBRI2; ITM2B; RDGCA
UniProt ID: (Human) Q96B24
Entrez Gene ID: (Human) 9445
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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