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For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ABri/ADan amyloid peptide; Bri; BRICHOS domain containing 2B; imBRI2; Immature BRI2; Integral membrane protein 2B; OTTHUMP00000018394; Protein E25B; RP11-196P14.1; Transmembrane protein BRI
Gene Aliases: ABRI; BRI; BRI2; BRICD2B; E25B; E3-16; FBD; imBRI2; ITM2B; RDGCA
UniProt ID: (Human) Q9Y287
Entrez Gene ID: (Human) 9445
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