Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
FIGURE: 1 / 1
Sequence of this protein is as follows: MVKISFQPAV AGIKGDKADK ASASAPAPAS ATEILLTPAR EEQPPQHRSK RGSSVGGVCY LSMGMVVLLM GLVFASVYIY RYFFLAQLAR DNFFRCGVLY EDSLSSQVRT QMELEEDVKI YLDENYERIN VPVPQFGGGD PADIIHDFQR RGTYLPQTYI IQEEMVVTEH VSDKEALGSF IYHLCNGKDT YRLRRRATRR RINKRGAKNC NAIRHFENTF VVETLICGVV
Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha-and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BRICHOS domain containing 2C; Cerebral protein 14; hRPC.1050_D_4; Integral membrane protein 2C; integral membrane protein 3; Transmembrane protein BRI3
Gene Aliases: BRI3; BRICD2C; E25; E25C; hucep-14; ITM2C; ITM3; NPD018; PSEC0047
UniProt ID: (Human) Q9NQX7
Entrez Gene ID: (Human) 81618
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support