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Invitrogen
Icatolimab Humanized Recombinant Human Monoclonal Antibody
Application
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Icatolimab Humanized Antibody (MA5-59403) in ELISA
ELISA analysis of Icatolimab Recombinant monoclonal antibody (Product # MA5-59403). Immobilized human BTLA His at 2 µg/mL can bind (icatolimab), EC50=0.01515 µg/mL.
Product Details
MA5-59403
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Human
/ IgG4SP
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Conjugate
Unconjugated
Form
Lyophilized
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
25mM histidine, pH 6.2, with 0.01% Tween 80, 8% sucrose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
AB_3682421
Product Specific Information
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
Target Information
Icatolimab, also known as JS004 or TAB004, is a humanized IgG4 monoclonal antibody with a hinge mutation (S228P) that targets B and T Lymphocyte Attenuator (BTLA) and inhibits its interaction with its ligand, Herpesvirus Entry Mediator (HVEM). BTLA (B and T lymphocyte attenuator), also known as CD272, is a member of the CD28 immunoglobulin-superfamily of co-inhibitory receptors. It is located on chromosome 3q13.2 in humans. Structurally, BTLA is characterized by an extracellular immunoglobulin-like variable domain and intracellular immunoreceptor tyrosine-based inhibition motifs (ITIMs). Functionally, BTLA is predominantly expressed on CD4+ and CD8+ T cells, B cells, and various other immune cells. It serves as a negative regulator of immune responses by transmitting inhibitory signals upon interaction with its ligand, HVEM (herpesvirus entry mediator). These interactions are crucial in maintaining immune homeostasis and preventing autoimmunity. BTLA expression decreases upon T cell activation and is implicated in various immune disorders and cancer, where it modulates immune evasion mechanisms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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