Invitrogen

Integrin alpha V (CD51) Polyclonal Antibody

View all (31) Integrin alpha V (CD51) antibodies
Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Product Details

PA5-120785

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunoprecipitation (IP)

0.5 µg- 4 µg
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 950-1048 of human Integrin alpha V (ITGAV/CD51) (NP_0022011)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.23 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.09% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2914357

Product Specific Information

Positive test controls include: MCF7, NIH/3T3, C6. The target is usually found in the following locations: Membrane, Single-pass type I membrane protein.

Immunogen sequence: FKRVRPPQEE QERE

Target Information

ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8, 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands, the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: alpha v integrin; antigen identified by monoclonal antibody L230; CD51; Dnmt3l-ps1 pseudogene; GP3A; integrin alpha V; Integrin alpha-V; integrin alphaVbeta3; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); ITGB3; Vitronectin receptor; vitronectin receptor alpha polypeptide (VNRA); Vitronectin receptor subunit alpha; VNR

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Gene Aliases: 1110004F14Rik; 2610028E01Rik; CD51; D430040G12Rik; ITGAV; MSK8; VNRA; VTNR

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UniProt ID: (Human) P06756, (Mouse) P43406

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Entrez Gene ID: (Human) 3685, (Rat) 296456, (Mouse) 16410

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Function(s)
virus receptor activity opsonin binding fibronectin binding protease binding protein kinase C binding voltage-gated calcium channel activity protein binding coreceptor activity fibroblast growth factor binding C-X3-C chemokine binding insulin-like growth factor I binding neuregulin binding metal ion binding transforming growth factor beta binding extracellular matrix binding extracellular matrix protein binding receptor binding peptide binding protein heterodimerization activity integrin
Process(es)
angiogenesis antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent cell adhesion cell-matrix adhesion integrin-mediated signaling pathway positive regulation of cell proliferation negative regulation of macrophage derived foam cell differentiation negative regulation of lipid storage cell growth cell migration extracellular matrix organization positive regulation of cell migration cell-substrate adhesion negative regulation of lipid transport positive regulation of osteoblast proliferation heterotypic cell-cell adhesion substrate adhesion-dependent cell spreading endodermal cell differentiation apolipoprotein A-I-mediated signaling pathway apoptotic cell clearance negative regulation of low-density lipoprotein particle receptor biosynthetic process positive regulation of cell adhesion viral entry into host cell vascular endothelial growth factor receptor signaling pathway negative regulation of lipoprotein metabolic process regulation of phagocytosis leukocyte migration negative chemotaxis entry of symbiont into host cell by promotion of host phagocytosis ERK1 and ERK2 cascade calcium ion transmembrane transport extrinsic apoptotic signaling pathway in absence of ligand regulation of apoptotic cell clearance negative regulation of entry of bacterium into host cell negative regulation of extrinsic apoptotic signaling pathway blood vessel development vasculogenesis cellular calcium ion homeostasis positive regulation of cytosolic calcium ion concentration positive regulation of MAPK cascade inflammatory response multicellular organism development fertilization cell differentiation detection of molecule of bacterial origin regulation of ion transmembrane transport gonad morphogenesis T cell activation endothelial cell migration regulation of bone resorption focal adhesion assembly release of sequestered calcium ion into cytosol trophoblast giant cell differentiation response to nitric oxide
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