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Product Details
PA5-11267
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 1101-1132 amino acids from the C-terminal region of human JAK2
Conjugate
Form
Liquid
Concentration
2 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2233994
Target Information
Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways and is mutated in polycythemia vera. This kinase contains the catalytic domain (JH1) of JAK2. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex. Mutations affecting JAK2 can cause Budd-Chiari syndrome, Polycythemia vera, Thrombocythemia 3, myelofibrosis, or Acute myelogenous leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: EC 2.7.10.2; JAK 2; JAK-2; Janus kinase 2; Janus kinase 2 (a protein tyrosine kinase); JTK 10; kinase Jak2; Tyrosine-protein kinase JAK2
Gene Aliases: Fd17; JAK2; JTK10; THCYT3
UniProt ID: (Human) O60674, (Mouse) Q62120
Entrez Gene ID: (Human) 3717, (Mouse) 16452
protein kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
Ras guanyl-nucleotide exchange factor activity
receptor binding
growth hormone receptor binding
interleukin-12 receptor binding
protein binding
ATP binding
protein C-terminus binding
protein kinase binding
heme binding
type 1 angiotensin receptor binding
acetylcholine receptor binding
histone kinase activity (H3-Y41 specific)
SH2 domain binding
histone binding
phosphatidylinositol 3-kinase binding
insulin receptor substrate binding
metal ion binding
peptide hormone receptor binding
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
MAPK cascade
activation of MAPKK activity
adaptive immune response
protein phosphorylation
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
movement of cell or subcellular component
signal transduction
enzyme linked receptor protein signaling pathway
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
JAK-STAT cascade
tyrosine phosphorylation of STAT protein
STAT protein import into nucleus
mesoderm development
blood coagulation
positive regulation of cell proliferation
negative regulation of cell proliferation
intrinsic apoptotic signaling pathway in response to oxidative stress
negative regulation of cardiac muscle cell apoptotic process
positive regulation of cell-substrate adhesion
positive regulation of phosphatidylinositol 3-kinase signaling
cell migration
peptidyl-tyrosine phosphorylation
cytokine-mediated signaling pathway
negative regulation of cell-cell adhesion
actin filament polymerization
cell differentiation
erythrocyte differentiation
positive regulation of cell migration
axon regeneration
mineralocorticoid receptor signaling pathway
positive regulation of insulin secretion
response to lipopolysaccharide
positive regulation of phosphoprotein phosphatase activity
positive regulation of interleukin-1 beta production
positive regulation of tumor necrosis factor production
positive regulation of protein import into nucleus, translocation
response to hydroperoxide
tumor necrosis factor-mediated signaling pathway
response to tumor necrosis factor
histone H3-Y41 phosphorylation
intracellular signal transduction
interleukin-12-mediated signaling pathway
peptidyl-tyrosine autophosphorylation
regulation of cell proliferation
tyrosine phosphorylation of Stat3 protein
tyrosine phosphorylation of Stat5 protein
tyrosine phosphorylation of Stat1 protein
positive regulation of tyrosine phosphorylation of Stat3 protein
positive regulation of tyrosine phosphorylation of Stat5 protein
activation of JAK2 kinase activity
regulation of apoptotic process
positive regulation of DNA binding
negative regulation of DNA binding
negative regulation of neuron apoptotic process
positive regulation of GTPase activity
innate immune response
positive regulation of nitric oxide biosynthetic process
positive regulation of cell differentiation
negative regulation of heart contraction
response to antibiotic
protein autophosphorylation
platelet-derived growth factor receptor signaling pathway
regulation of inflammatory response
positive regulation of inflammatory response
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of cell activation
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of nitric-oxide synthase biosynthetic process
interferon-gamma-mediated signaling pathway
regulation of interferon-gamma-mediated signaling pathway
growth hormone receptor signaling pathway
JAK-STAT cascade involved in growth hormone signaling pathway
positive regulation of growth hormone receptor signaling pathway
mammary gland epithelium development
response to interleukin-12
extrinsic apoptotic signaling pathway
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
immune system process
response to oxidative stress
transmembrane receptor protein tyrosine kinase signaling pathway
hormone-mediated signaling pathway
phosphorylation
chromatin modification
myeloid cell differentiation
regulation of cell adhesion
host programmed cell death induced by symbiont
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of transcription from RNA polymerase II promoter
cellular response to lipopolysaccharide
cellular response to dexamethasone stimulus
response to granulocyte macrophage colony-stimulating factor
positive regulation of apoptotic signaling pathway
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