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This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.
Jumonji domain-containing protein 2C (JMJD2C)/ Lysine-specific demethylase 4C (KDM4C) is a histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3; thereby, playing a central role in histone code. KDM4C does not demethylate histone H3 'Lys-4', H3 'Lys-27', or H4 'Lys-20'. It demethylates trimethylated H3 "Lys-9' and H3 "Lys-36' residues. There is no activity on mono- or dimethylated residues. Demethylation of Lys residues generates formaldehyde and succinate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: [histone H3]-trimethyl-L-lysine(9) demethylase 4C; bA146B14.1; GASC-1 protein; gene amplified in squamous cell carcinoma 1; Gene amplified in squamous cell carcinoma 1 protein; JmjC domain-containing histone demethylation protein 3C; jumonji domain containing 2C; Jumonji domain-containing protein 2C; lysine (K)-specific demethylase 4C; Lysine-specific demethylase 4C; RP11-169L18.1; tudor domain containing 14C
Gene Aliases: 2410141F18Rik; AA517467; GASC1; JHDM3C; JMJD2C; KDM4C; KIAA0780; TDRD14C
UniProt ID: (Human) Q9H3R0, (Mouse) Q8VCD7
Entrez Gene ID: (Human) 23081, (Mouse) 76804
Molecular Function:
histone modifying enzyme
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