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Product Details
PA5-77605
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide DPKSAAQNSKPRLSFSTK(C), corresponding to residues 8-25 of human K2P 2.1 (TREK-1)
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2736002
Product Specific Information
Product is shipped at room temperature as a lyophilized powder and should be stored at -20C upon receipt.
Reconstitute using 50 uL deionized water.
Target Information
TREK-1 is a two-pore-domain background potassium channel expressed throughout the central nervous system. It is opened by polyunsaturated fatty acids and lysophospholipids. As well, it is regulated by various neurotransmitters. It has been shown that alterations in the functioning, regulation, or both of the TREK-1 channel may alter mood. TREK-1 is also activated by volatile anesthetics and has been suggested to be an important target in the action of these drugs. Therefore, this particular K+ channel emerges as a potential innovative target for developing new therapeutic agents for anesthesiology and neurology, such as antidepressants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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