Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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Immunogen sequence: SHSSHSSQSS SKKSSSVHSI PSTANRPNRP KSRESRDKQN ATRMTRMGQA EKKWFTDEPD NAYPRNIQIK PMSTHMANQI NQYKSTSSLI PPIREVEDEC
Reconstitution: 1 X 25 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BK channel; BK channel alpha subunit; BKCA alpha; calcium-activated potassium channel alpha subunit; Calcium-activated potassium channel subunit alpha-1; Calcium-activated potassium channel, subfamily M subunit alpha-1; K(VCA)alpha; KCa1.1; Maxi K channel; MaxiK; mSlo1; potassium large conductance calcium-activated channel, subfamily M, alpha member 1; Slo homolog; Slo-alpha; Slo1; Slowpoke homolog
Gene Aliases: 5730414M22Rik; BKCa; Kcnma; Kcnma1; KCNMA1b; KCNMA1c; MaxiK; mSlo; mSlo1; Slo; Slo1
UniProt ID: (Mouse) Q08460, (Rat) Q62976
Entrez Gene ID: (Mouse) 16531, (Rat) 83731
Molecular Function:
ion channel
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