Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Application
FIGURE: 1 / 1
KCNN3 (KCa2.3, SK3) Antibody (APC-025-AR-50UL) in IHC (F)
Expression of KCa2.3 (SK3) in rat brain - Immunohistochemical staining of rat brain perfusion-fixed frozen sections using Anti-KCNN3 (KCa2.3, SK3) (N-term)-ATTO Fluor-594 Antibody (#APC-025-AR). A. SK3channel (red) is visualized in the rat substantia nigra pars compacta. B. Pre-incubation of the Anti-KCNN3 (KCa2.3, SK3) (N-term)-ATTO Fluor-594 Antibody with the immunogen peptide, blocks specific staining. D... View More
Product Details
APC-025-AR-50UL
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DTSGHFHDSGVGDLDEDPKC, corresponding to amino acid residues 2-21 of human KCNN3, Intracellular, N-terminus
Conjugate
Atto™ 594
Excitation/Emission Max
602/622 nm
Form
Lyophilized
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. KCNN3, a member of the KCNN family of potassium channel genes, encodes a protein that is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: KCa2.3; potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3; SK3; SKCa 3; SKCa3; small conductance calcium-activated potassium channel 3; Small conductance calcium-activated potassium channel protein 3; small-conductance Ca2+-activated K+ channel 3
Gene Aliases: hSK3; K3; KCa2.3; KCNN3; SK3; SKCA3
UniProt ID: (Human) Q9UGI6, (Mouse) P58391, (Rat) P70605
Entrez Gene ID: (Human) 3782, (Mouse) 140493, (Rat) 54263
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support