Alomone Labs, LTD

KCNQ1 Polyclonal Antibody

View all (19) KCNQ1 antibodies
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Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

APC-022-GP200UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Guinea pig / IgG

Class

Polyclonal

Type

Antibody

Immunogen

(C)TYEQLTVPRRGPDEGS, corresponding to amino acid residues 661-676 of human KCNQ1, Intracellular, C-terminus
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.8 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Information

Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. A specific K+ channel, comprised of an alpha subunit KCNQ1 and a beta subunit KCNE1, a small protein which spans the membrane only once, is predominantly expressed in the heart and in the cochlea, and is responsible for regulating the slow, depolarization-activated potassium current. Mutations in the genes encoding for KCNQ1 and KCNE1 lead to cardiac disease because they directly impair electrical signaling, and mutations in KCNQ4 are implicated in the onset of deafness. KCNQ proteins, including KCNQ1 and KCNQ4, characteristically contain six transmembrane domains and function as tetramers. KCNQ4 forms heteromeric channels with KCNQ3 and is expressed in several tissues, including the cochlea, where it is present in outer hair cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FLJ26167; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; kidney and cardiac voltage dependend K+ channel; KQT-like 1; potassium channel, voltage gated KQT-like subfamily Q, member 1; Potassium voltage-gated channel subfamily KQT member 1; potassium voltage-gated channel, KQT-like subfamily, member 1; potassium voltage-gated channel, subfamily Q, member 1; slow delayed rectifier channel subunit; Voltage-gated potassium channel subunit Kv7.1

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Gene Aliases: ATFB1; ATFB3; AW559127; JLNS1; KCNA8; KCNA9; KCNQ1; Kv1.9; Kv7.1; KVLQT1; LQT; LQT1; RWS; SQT2; WRS

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UniProt ID: (Human) P51787, (Mouse) P97414, (Rat) Q9Z0N7

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Entrez Gene ID: (Human) 3784, (Mouse) 16535, (Rat) 84020

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Function(s)
voltage-gated potassium channel activity delayed rectifier potassium channel activity protein binding calmodulin binding phosphatidylinositol-4,5-bisphosphate binding protein phosphatase 1 binding outward rectifier potassium channel activity protein kinase A catalytic subunit binding protein kinase A regulatory subunit binding ion channel binding voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization scaffold protein binding voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization ion channel activity voltage-gated ion channel activity potassium channel activity protein homodimerization activity voltage-gated ion channel
Process(es)
positive regulation of defense response to virus by host regulation of gene expression by genetic imprinting sensory perception of sound regulation of heart contraction positive regulation of heart rate gene silencing cellular response to drug inner ear development intestinal absorption cardiac muscle contraction regulation of membrane repolarization regulation of ventricular cardiac muscle cell membrane repolarization regulation of atrial cardiac muscle cell membrane repolarization positive regulation of cardiac muscle contraction regulation of gastric acid secretion cardiac conduction renal absorption cellular response to cAMP potassium ion export potassium ion transmembrane transport cellular response to epinephrine stimulus cardiovascular system development ventricular cardiac muscle cell action potential membrane repolarization during action potential membrane repolarization during cardiac muscle cell action potential atrial cardiac muscle cell action potential regulation of heart rate by cardiac conduction potassium ion export across plasma membrane xenophagy membrane repolarization during ventricular cardiac muscle cell action potential positive regulation of potassium ion transmembrane transport transport ion transport potassium ion transport regulation of ion transmembrane transport regulation of membrane potential negative regulation of insulin secretion transmembrane transport positive regulation of gastric acid secretion response to anesthetic male gonad development
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