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            • Primary Antibodies ›
            • KDM5A Antibodies

            Invitrogen

            KDM5A Polyclonal Antibody

            View all (12) KDM5A antibodies
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            Cite KDM5A Polyclonal Antibody

            • Antibody Testing Data (2)
            Application
            KDM5A Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            Group 53 Created with Sketch.

            FIGURE: 1 / 2

            KDM5A Antibody (PA5-103448) in IHC (P)

            Immunohistochemistry analysis of KDM5A in rat heart tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with KDM5A polyclonal antibody (Product # PA5-103448) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
            View Product

            KDM5A Antibody in Immunohistochemistry (Paraffin) (IHC (P))
            KDM5A Antibody in Western Blot (WB)

            Product Details

            PA5-103448

            Applications
            Tested Dilution
            Publications

            Western Blot (WB)

            1:1,000-1:3,000
            -

            Immunohistochemistry (Paraffin) (IHC (P))

            1:50-1:200
            -
            Product Specifications

            Species Reactivity

            Human, Mouse

            Host/Isotype

            Rabbit / IgG

            Class

            Polyclonal

            Type

            Antibody

            Immunogen

            A synthesized peptide derived from human KDM5A(Accession P29375), corresponding to amino acid residues E1384-V1434.
            View immunogen

            Conjugate

            Unconjugated

            Form

            Liquid

            Concentration

            1 mg/mL

            Purification

            Affinity chromatography

            Storage buffer

            PBS, pH 7.4, with 50% glycerol

            Contains

            0.02% sodium azide

            Storage conditions

            -20°C

            Shipping conditions

            Ambient (domestic); Wet ice (international)

            RRID

            AB_2852789

            Product Specific Information

            Antibody detects endogenous levels of total KDM5A.

            Target Information

            UPF3B is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The protein is one of two functional homologs to yeast Upf3p. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctionsThis gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene.

            For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

            References (0)

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            Cite this product

            Bioinformatics

            Protein Aliases: [histone H3]-trimethyl-L-lysine(4) demethylase 5A; Histone demethylase JARID1A; jumonji, AT rich interactive domain 1A (Rbp2 like); Jumonji, AT rich interactive domain 1A (RBP2-like); Jumonji/ARID domain-containing protein 1A; lysine (K)-specific demethylase 5A; Lysine-specific demethylase 5A; RBBP-2; retinoblastoma binding protein 2; Retinoblastoma-binding protein 2

            View more View less

            Gene Aliases: AA409370; C76986; JARID1A; KDM5A; RBBP-2; RBBP2; RBP2

            View more View less

            UniProt ID: (Human) P29375, (Mouse) Q3UXZ9

            View more View less

            Entrez Gene ID: (Human) 5927, (Mouse) 214899

            View more View less

            Function(s)

            DNA binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity protein binding zinc ion binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors chromatin DNA binding histone demethylase activity sulfonate dioxygenase activity chromatin binding oxidoreductase activity 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity procollagen-proline dioxygenase activity hypophosphite dioxygenase activity DNA-N1-methyladenine dioxygenase activity metal ion binding dioxygenase activity C-19 gibberellin 2-beta-dioxygenase activity C-20 gibberellin 2-beta-dioxygenase activity histone modifying enzyme

            Process(es)

            negative regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter spermatogenesis male gonad development circadian regulation of gene expression histone H3-K4 demethylation positive regulation of transcription, DNA-templated oxidation-reduction process negative regulation of histone deacetylase activity transcription, DNA-templated regulation of transcription, DNA-templated multicellular organism development chromatin modification rhythmic process regulation of nucleic acid-templated transcription
            It has to be done as per old AB suggested Products section.
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