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The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants.
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Protein Aliases: Krueppel-like factor 7; Kruppel-like factor 7 (ubiquitous); Ubiquitous krueppel-like factor; ubiquitous Kruppel-like factor; ubiquitous Kruppel-like transcription factor
Gene Aliases: KLF7; UKLF
UniProt ID: (Human) O75840
Entrez Gene ID: (Human) 8609
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