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Abnova
KRIT1 Monoclonal Antibody (2C7)
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Product Details
H00000889-M01
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, lambda
Class
Monoclonal
Type
Antibody
Clone
2C7
Immunogen
KRIT1 (NP_004903, 637 a.a. approximately 736 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: AAFFTGQIFT KASPSNHKVI PVYVGVNIKG LHLLNMETKA LLISLKYGCF MWQLGDTDTC FQIHSMENKM SFIVHTKQAG LVVKLLMKLN GQLMPTERNS
Target Information
This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ankyrin repeat-containing protein Krit1; Cerebral cavernous malformations 1 protein; Krev interaction trapped 1; Krev interaction trapped protein 1
Gene Aliases: CAM; CCM1; KRIT1
UniProt ID: (Human) O00522
Entrez Gene ID: (Human) 889
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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