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Product Details
PA5-99825
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human KRT84(Accession Q9NSB2), corresponding to amino acid residues G550-Y600.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2818758
Product Specific Information
Antibody detects endogenous levels of total KRT84.
Target Information
The Keratin multigene family is made of "soft" epithelial cytokeratins and "hard" hair Keratins. While the epithelial cytokeratins are involved in the layering and formation of epithelia, the hair Keratins are responsible for creating nails and hair. There are two types of Keratins: the acidic class I Keratin proteins and the basic/neutral class II Keratin proteins. Keratin 84, also known as KRT84, HB4 or KRTHB4, is a 600 amino acid protein that is expressed in hair follicles. Keratin 84 is a basic/neutral type II Keratin protein which heterodimerizes with type I Keratins to create hair and nails. The gene encoding Keratin 84 maps to human chromosome 12 which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis and Kniest dysplasia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 65 kDa type II keratin; hard keratin, type II, 4; K84; keratin 84, type II; keratin complex 2, basic, gene 16; keratin complex 2, gene 16; keratin, hair, basic, 4; Keratin, type II cuticular Hb4; Keratin-84; type II hair keratin 4; Type II hair keratin Hb4; type II keratin Kb24; Type-II keratin Kb24
Gene Aliases: AV235125; HB4; HRb-1; Kb24; Krt2-16; Krt2-3; KRT84; KRTHB4
UniProt ID: (Human) Q9NSB2, (Mouse) Q99M73
Entrez Gene ID: (Human) 3890, (Mouse) 16680, (Rat) 315320
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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