Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
KLOTHO is the systemic anti-aging hormone within the glycosidase1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, a deficiency in KLOTHO expression leads to various systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy together with growth retardation, short life-span and infertility. Transgenic mice overexpressing KLOTHO have an extended life span by inhibiting insulin/IGF1 signaling. KLOTHO is involved in the regulation of calcium/phosphorus homeostasis by inhibiting the synthesis of active vitamin D and identified as a potential tumor suppressor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HFTC3; Klotho
Gene Aliases: KL
UniProt ID: (Human) Q9UEF7, (Rat) Q9Z2Y9
Entrez Gene ID: (Human) 9365, (Rat) 83504
Molecular Function:
glycosidase
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