Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Invitrogen
This antibody recognizes L3MBTL1 (Lethal(3)malignant brain tumor-like protein 1). It binds to a folded domain, amino acids 200-530. L3MBTL1 is a Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications.
L3MBTL1 is the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion-mother cells in the optic centers of the brain. L3MBTL1 is localized to condensed chromosomes in mitotic cells and overexpression of this protein in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells. L3MBTL1 represents a polycomb group gene the encoded protein functions to regulate gene activity, likely via chromatin modification. Polycomb group protein specifically recognizes and binds mono- and dimethyllysine residues on target proteins, thereby acting as a reader of a network of post-translational modifications. Alternatively spliced transcript variants encoding different isoforms of the L3MBTL1 gene have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: H-l(3)mbt; L(3)mbt protein homolog; L3MBTL1; lethal (3) malignant brain tumor l(3); Lethal(3)malignant brain tumor-like protein 1; RP1-138B7.1
Gene Aliases: dJ138B7.3; H-L(3)MBT; KIAA0681; L3MBT; L3MBTL; L3MBTL1; ZC2HC3
UniProt ID: (Human) Q9Y468
Entrez Gene ID: (Human) 26013
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