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NRIP is a novel 860a.a nuclear protein consisting of seven conserved WD40 domains and one NLS motif. It binds to androgen and glucocorticoid receptors and up regulates their transcriptional activity, thereby functioning as a nuclear receptor coactivator. Role of NRIP has been implicated in cell growth and also in cervical and prostrate cancer thus indicating a therapeutic intervention. Northern Blot analysis detected a high expression of NRIP in skeletal muscle and testis and low expression in heart, prostrate and adrenal gland.
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Protein Aliases: 40 kDa erythrocyte membrane protein; G protein-coupled receptor 69; G protein-coupled receptor 69A; Glutathione S-transferase LANCL1; LanC (bacterial lantibiotic synthetase component C)-like 1; LanC (bacterial lantibiotic synthetase component); LanC lantibiotic synthetase component C-like 1; LanC-like protein 1; p40
Gene Aliases: AW124738; Gpr69; GPR69A; LANCL1; p40
UniProt ID: (Human) O43813, (Mouse) O89112
Entrez Gene ID: (Human) 10314, (Mouse) 14768
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