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Product Details
BS-4213R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human LARG, amino acids 515-615.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: leukemia-associated Rho guanine nucleotide exchange factor; leukemia-associated Rho guanine-nucleotide exchange factor; Leukemia-associated RhoGEF; Rho guanine nucleotide exchange factor (GEF) 12; Rho guanine nucleotide exchange factor 12
Gene Aliases: 2310014B11Rik; ARHGEF12; AU019857; KIAA0382; LARG; mKIAA0382; PRO2792
UniProt ID: (Human) Q9NZN5
Entrez Gene ID: (Human) 23365, (Rat) 367072, (Mouse) 69632
G-protein coupled receptor signaling pathway
regulation of Rho protein signal transduction
intracellular signal transduction
positive regulation of apoptotic process
positive regulation of GTPase activity
regulation of small GTPase mediated signal transduction
biological_process
termination of G-protein coupled receptor signaling pathway
Performance Guarantee
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