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Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MLWRVLLSKR PPFPHPELDF QEAPIPSCPG RLPGRKNSVA LAAAPRKEPT GDREKPLPFP VLAPFSNPEH SAPAKVVRAA VPKQRKGSKV GDFGDAINWP TPGEIAHKSV QPQSHKPQPT RKLPPKKDMK EQEKGEGSDS KESPKTKSDE SGEEKNGDED CQRGGQKKKG NKHKWVPLQI DMKPEVPREK LASRPTRPPE PRHIPANRGE IKGSESATYV PVAPPTPAWQ PEIKPEPAWH DQDETSSVKS DGAGGARASF RGRGRGRGRG RGRGRGGTRT HFDYQFGYRK FDGVEGPRTP KYMNNITYYF DNVSSTELYS VDQELLKDYI KRQIEYYFSV DNLERDFFLR RKMDADGFLP ITLIASFHRV QALTTDISLI FAALKDSKVV EIVDEKVRRR EEPEKWPLPP IVDYSQTDFS QLLNCPEFVP RQHYQKETES APGSPRAVTP VPTKTEEVSN LKTLPKGLSA SLPDLDSENW IEVKKRPRPS PARPKKSEES RFSHLTSLPQ QLPSQQLMSK DQDEQEELDF LFDEEMEQMD GRKNTFTAWS DEESDYEIDD RDVNKILIVT QTPHYMRRHP GGDRTGNHTS RAKMSAELAK VINDGLFYYE QDLWAEKFEP EYSQIKQEVE NFKKVNMISR EQFDTLTPEP PVDPNQEVPP GPPRFQQVPT DALANKLFGA PEPSTIARSL PTTVPESPNY RNTRTPRTPR TPQLKDSSQT SRFYPVVKEG RTLDAKMPRK RKTRHSSNPP LESHVGWVMD SREHRPRTAS ISSSPSEGTP TVGSYGCTPQ SLPKFQHPSH ELLKENGFTQ HVYHKYRRRC LNERKRLGIG QSQEMNTLFR FWSFFLRDHF NKKMYEEFKQ LALEDAKEGY RYGLECLFRY YSYGLEKKFR LDIFKDFQEE TVKDYEAGQL YGLEKFWAFL KYSKAKNLDI DPKLQEYLGK FRRLEDFRVD PPMGEEGNHK RHSVVAGGGG GEGRKRCPSQ SSSRPAAMIS QPPTPPTGQP VREDAKWTSQ HSNTQTLGK
RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed:20430826, PubMed:23711370, PubMed:24532714, PubMed:25940091, PubMed:28650797, PubMed:28673543, PubMed:29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed:23711370, PubMed:25940091, PubMed:28650797, PubMed:29244122, PubMed:26206669, PubMed:28379136). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed:25940091, PubMed:28650797, PubMed:29244122, PubMed:28379136). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed:25940091, PubMed:28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed:28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed:20430826, PubMed:24532714, PubMed:25940091, PubMed:28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed:23711370, PubMed:28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed:20430826, PubMed:24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed:20430826, PubMed:23711370, PubMed:25940091, PubMed:28673543). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: La ribonucleoprotein domain family member 1; La ribonucleoprotein domain family, member 1; La-related protein 1
Gene Aliases: KIAA0731; LARP; LARP1
UniProt ID: (Human) Q6PKG0
Entrez Gene ID: (Human) 23367
Molecular Function:
RNA metabolism protein
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