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Proteintech

LBR Polyclonal Antibody

13 References

View all (12) Lamin B Receptor antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (9)

Application

LBR Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 9

LBR Antibody (12398-1-AP) in ICC/IF

Immunofluorescent analysis of (-20°C Ethanol) fixed HeLa cells using 12398-1-AP (LBR antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).

LBR Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

12398-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 6 publications 6 publications

Immunocytochemistry (ICC/IF)

1:25-1:100

View 4 publications 4 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

LBR Fusion Protein Ag3088 (1-210 aa encoded by BC020079)

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

0.21 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MPSRKFADG EVVRGRWPGS SLYYEVEILS HDSTSQLYTV KYKDGTELEL KENDIKPLTS FRQRKGGSTS SSPSRRRGSR SRSRSRSPGR PPKSARRSAS ASHQADIKEA RREVEVKLTP LILKPFGNSI SRYNGEPEHI ERNDAPHKNT QEKFSLSQES SYIATQYSLR PRREEVKLKE IDSKEEKYVA KELAVRTFEV TPIRAKDLEF G (1-210 aa encoded by BC020079)

Target Information

The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The perinuclear theca protein Calicin helps shape the sperm head and maintain the nuclear structure in mice.

Cell reports

Zhang XZ,Wei LL,Jin HJ,Zhang XH,Chen SR

Tue Jul 05 00:00:00 UTC 2022

Novel long non-coding RNA CYB561-5 promotes aerobic glycolysis and tumorigenesis by interacting with basigin in non-small cell lung cancer.

Journal of cellular and molecular medicine

Li L,Li Z,Qu J,Wei X,Suo F,Xu J,Liu X,Chen C,Zheng S

Tue Mar 01 00:00:00 UTC 2022

Novel long non-coding RNA CYB561-5 promotes aerobic glycolysis and tumorigenesis by interacting with basigin in non-small cell lung cancer.

Journal of cellular and molecular medicine

Li L,Li Z,Qu J,Wei X,Suo F,Xu J,Liu X,Chen C,Zheng S

Tue Mar 01 00:00:00 UTC 2022

Fast detection, a precise and sensitive diagnostic agent for breast cancer.

Journal of experimental & clinical cancer research : CR

Wu Q,Yuan C,Liu N,Shu J,Wang J,Qian J,Zeng L,Zhang H,Wang X,Mei W

Mon Jun 13 00:00:00 UTC 2022

Oleuropein ameliorated lung ischemia-reperfusion injury by inhibiting TLR4 signaling cascade in alveolar macrophages.

Transplant immunology

Xu Z,Sun X,Ding B,Zi M,Ma Y

Sat Oct 01 00:00:00 UTC 2022

Interaction of tau with HNRNPA2B1 and N⁶-methyladenosine RNA mediates the progression of tauopathy.

Molecular cell

Jiang L,Lin W,Zhang C,Ash PEA,Verma M,Kwan J,van Vliet E,Yang Z,Cruz AL,Boudeau S,Maziuk BF,Lei S,Song J,Alvarez VE,Hovde S,Abisambra JF,Kuo MH,Kanaan N,Murray ME,Crary JF,Zhao J,Cheng JX,Petrucelli L,Li H,Emili A,Wolozin B

Thu Oct 21 00:00:00 UTC 2021

RCC1L (WBSCR16) isoforms coordinate mitochondrial ribosome assembly through their interaction with GTPases.

PLoS genetics

Reyes A,Favia P,Vidoni S,Petruzzella V,Zeviani M

Wed Jul 01 00:00:00 UTC 2020

PRC1 collaborates with SMCHD1 to fold the X-chromosome and spread Xist RNA between chromosome compartments.

Nature communications

Wang CY,Colognori D,Sunwoo H,Wang D,Lee JT

Wed Jul 03 00:00:00 UTC 2019

A common pathomechanism in GMAP-210- and LBR-related diseases.

JCI insight

Wehrle A,Witkos TM,Schneider JC,Hoppmann A,Behringer S,Köttgen A,Elting M,Spranger J,Lowe M,Lausch E

Thu Dec 06 00:00:00 UTC 2018

A common pathomechanism in GMAP-210- and LBR-related diseases.

JCI insight

Wehrle A,Witkos TM,Schneider JC,Hoppmann A,Behringer S,Köttgen A,Elting M,Spranger J,Lowe M,Lausch E

Thu Dec 06 00:00:00 UTC 2018

A common pathomechanism in GMAP-210- and LBR-related diseases.

JCI insight

Wehrle A,Witkos TM,Schneider JC,Hoppmann A,Behringer S,Köttgen A,Elting M,Spranger J,Lowe M,Lausch E

Thu Dec 06 00:00:00 UTC 2018

A common pathomechanism in GMAP-210- and LBR-related diseases.

JCI insight

Wehrle A,Witkos TM,Schneider JC,Hoppmann A,Behringer S,Köttgen A,Elting M,Spranger J,Lowe M,Lausch E

Thu Dec 06 00:00:00 UTC 2018

Interactome Analysis Reveals a Novel Role for RAD6 in the Regulation of Proteasome Activity and Localization in Response to DNA Damage.

Molecular and cellular biology

An H,Yang L,Wang C,Gan Z,Gu H,Zhang T,Huang X,Liu Y,Li Y,Chang SJ,Lai J,Li YB,Chen S,Sun FL

Wed Mar 15 00:00:00 UTC 2017

Interactome Analysis Reveals a Novel Role for RAD6 in the Regulation of Proteasome Activity and Localization in Response to DNA Damage.

Molecular and cellular biology

An H,Yang L,Wang C,Gan Z,Gu H,Zhang T,Huang X,Liu Y,Li Y,Chang SJ,Lai J,Li YB,Chen S,Sun FL

Wed Mar 15 00:00:00 UTC 2017

Interactome Analysis Reveals a Novel Role for RAD6 in the Regulation of Proteasome Activity and Localization in Response to DNA Damage.

Molecular and cellular biology

An H,Yang L,Wang C,Gan Z,Gu H,Zhang T,Huang X,Liu Y,Li Y,Chang SJ,Lai J,Li YB,Chen S,Sun FL

Wed Mar 15 00:00:00 UTC 2017

Interactome Analysis Reveals a Novel Role for RAD6 in the Regulation of Proteasome Activity and Localization in Response to DNA Damage.

Molecular and cellular biology

An H,Yang L,Wang C,Gan Z,Gu H,Zhang T,Huang X,Liu Y,Li Y,Chang SJ,Lai J,Li YB,Chen S,Sun FL

Wed Mar 15 00:00:00 UTC 2017

Emery-Dreifuss muscular dystrophy mutations impair TRC40-mediated targeting of emerin to the inner nuclear membrane.

Journal of cell science

Pfaff J,Rivera Monroy J,Jamieson C,Rajanala K,Vilardi F,Schwappach B,Kehlenbach RH

Mon Feb 01 00:00:00 UTC 2016

Emery-Dreifuss muscular dystrophy mutations impair TRC40-mediated targeting of emerin to the inner nuclear membrane.

Journal of cell science

Pfaff J,Rivera Monroy J,Jamieson C,Rajanala K,Vilardi F,Schwappach B,Kehlenbach RH

Mon Feb 01 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: 3-beta-hydroxysterol Delta (14)-reductase; C-14 sterol reductase; C14SR; Delta(14)-sterol reductase LBR; Delta-14-SR; FLJ43126; ichthyosis; Integral nuclear envelope inner membrane protein; Lamin-B receptor; LMN2R; MGC9041; PRO0650; Sterol C14-reductase; tudor domain containing 18

Gene Aliases: AI505894; DHCR14B; ic; LBR; LMN2R; Nbp60; PHA; TDRD18

UniProt ID: (Human) Q14739, (Mouse) Q3U9G9

Entrez Gene ID: (Human) 3930, (Mouse) 98386, (Rat) 89789

Function(s)

DNA binding protein binding lamin binding oxidoreductase activity, acting on the CH-CH group of donors poly(A) RNA binding delta14-sterol reductase activity chromo shadow domain binding nuclear localization sequence binding oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor chaperone binding reductase

Process(es)

cholesterol biosynthetic process sterol biosynthetic process oxidation-reduction process nuclear envelope organization mitotic nuclear division

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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LBR Polyclonal Antibody

LBR Antibody (12398-1-AP) in ICC/IF

Product Details

12398-1-AP

Western Blot (WB)

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Function(s)

Process(es)

Performance Guarantee

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