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Invitrogen
LDB3 Polyclonal Antibody
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Product Details
PA5-100276
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human LDB3(Accession O75112), corresponding to amino acid residues T522-P572.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2815806
Product Specific Information
Antibody detects endogenous levels of total LDB3.
Target Information
This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified; all isoforms have N-terminal PDZ domains while only longer isoforms (1, 2 and 5) have C-terminal LIM domains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cardiomyopathy, dilated 1C (autosomal dominant); cypher; FLJ35865; HGNC:15710; KIAA01613; LDB3; LIM domain-binding protein 3; oracle protein; PDZ and LIM domain 6; PDZ-LIM domain protein; Protein cypher; Protein oracle; Z-band alternatively spliced PDZ motif protein; Z-band alternatively spliced PDZ-motif protein
Gene Aliases: AW742271; CMD1C; CMH24; CMPD3; CYPHER; KIAA0613; LDB3; LDB3Z1; LDB3Z4; LVNC3; MFM4; ORACLE; PDLIM6; RGD1564875; ZASP
UniProt ID: (Human) O75112, (Mouse) Q9R0Z1
Entrez Gene ID: (Human) 11155, (Mouse) 24131, (Rat) 498587
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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