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Product Details
PA1-9064
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids ENVYESIKEMGL.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2136804
Product Specific Information
This antibody is predicted to react with rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000.
Target Information
LIME (Lck-interacting molecule) is a 30 kDa double-palmitoylated protein with unusually basic cytoplasmic domain, expressed by T cells. After ligation of CD4 or CD8 T cell coreceptors, LIME is phosphorylated by Src-family kinases and associates with Lck and Fyn kinases and with their negative regulator Csk. Interestingly, Csk-mediated phosphorylation of C-terminal negative-regulatory tyrosine of LIME-associated Lck can result in increase of enzymatic activity compared with the total pool of Lck, thus, LIME serves as a positive regulator of TCR-dependent T cell signaling. However, under some circumstances, LIME may mediate inhibitory signals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ20406; Lck-interacting molecule; Lck-interacting transmembrane adapter 1; lime 1; RP4-583P15.5
Gene Aliases: 2810038K19Rik; LIME; Lime1
UniProt ID: (Mouse) Q9EQR5
Entrez Gene ID: (Mouse) 72699
immune system process
regulation of transcription from RNA polymerase II promoter
regulation of phosphatidylinositol 3-kinase signaling
regulation of NF-kappaB import into nucleus
regulation of I-kappaB kinase/NF-kappaB signaling
regulation of MAP kinase activity
T cell receptor signaling pathway
B cell receptor signaling pathway
regulation of release of sequestered calcium ion into cytosol
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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