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Application
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LINGO2 Antibody (MA5-24121) in WB
Western blot analysis of LINGO2 in SH‚SY5Y human neuroblastoma cell line. Samples were incubated in LINGO2 monoclonal antibody (Product # MA5-24121) using a dilution of 2 µg/mL followed by a HRP-conjugated Anti-Mouse IgG secondary antibody. A specific band was detected for LINGO‚2 at approximately 75 kDa (as indicated). This experiment was conducted under reducing conditions.
Product Details
MA5-24121
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
382007
Immunogen
Mouse myeloma cell line NS0-derived recombinant human LINGO-2 Cys28-Leu542
Conjugate
Unconjugated
Form
Lyophilized
Concentration
0.5 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2607097
Product Specific Information
In direct ELISAs and Western blots, no cross-reactivity with recombinant human LINGO-1 is observed.
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
Leucine-rich repeat and immunoglobulin-like domain-containing protein 2 (LINGO2) is a gene located on chromosome 9q34.3, encoding a transmembrane protein predominantly expressed in the central nervous system. Structurally, LINGO2 features leucine-rich repeat (LRR) domains and immunoglobulin-like domains, which are crucial for molecular interactions and signaling. Functionally, LINGO2 is involved in regulating neural growth and development, influencing processes such as axon guidance and synaptic plasticity. It modulates neurotransmitter receptor activity and intracellular signaling pathways essential for neural transmission, with implications for both normal cognitive function and neurological disorders. Altered expression of LINGO2 has been associated with movement disorders, as well as neurodegenerative conditions, suggesting its role in neural circuit integrity. Current research on LINGO2 is exploring its potential as a therapeutic target for enhancing neural repair mechanisms and addressing synaptic dysfunction, providing insights into interventions for neurological diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: LERN3FLJ31810; leucine rich repeat neuronal 6C; Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2; Leucine-rich repeat neuronal protein 3; Leucine-rich repeat neuronal protein 6C
Gene Aliases: LERN3; LINGO2; LRRN6C; UNQ9234/PRO31993
UniProt ID: (Human) Q7L985
Entrez Gene ID: (Human) 158038
Performance Guarantee
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