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This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%
LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.
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Protein Aliases: Cysteine-rich protein TTG-2; LIM domain only protein 2; LIM only 2; LMO-2; Rhombotin-2; T-cell translocation protein 2
Gene Aliases: Lmo2; Rbtn-2; Rbtn2; Rhom-2; Ttg2
UniProt ID: (Mouse) P25801
Entrez Gene ID: (Mouse) 16909
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