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Immunogen sequence: AIDAPKTCSP KQFACRDQIT CISKGWRCDG ERDCPDGSDE APEICPQSKA QRCQPNEHNC LGTELCVPMS RLCNGVQDCM DGSDEGPHCR ELQGNCSRLG CQHHCVPTLD GPTCYCNSSF QLQADGKTCK DFDECSVYGT CSQLCTNTDG SFICGCVEGY LLQPDNRSCK AKNEPVDRPP VLLIANSQNI LATYLSGAQV STITPTSTRQ TTAMDFSYAN ETVCWVHVGD SAAQTQLKCA RMPGLKGFVD EHTINISLSL HLCVFSKSQQ EMG
The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients.
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Protein Aliases: A2MR; alpha 2-macroglobulin receptor; Alpha-2-macroglobulin receptor; APOER; Apolipoprotein E receptor; CD91; FLJ16451; lipoprotein receptor-related protein; low density lipoprotein receptor-related protein 1; LRP-1; lrp1; MGC88725; Prolow-density lipoprotein receptor-related protein 1; TbetaR-V/LRP-1/IGFBP-3 receptor; type V tgf-beta receptor
Gene Aliases: A2MR; AI316852; APOER; APR; b2b1554Clo; CD91; IGFBP3R; LRP; LRP1; LRP1A; TGFBR5
UniProt ID: (Human) Q07954, (Mouse) Q91ZX7
Entrez Gene ID: (Human) 4035, (Mouse) 16971
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