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Invitrogen

LRP1 Monoclonal Antibody (8G1)

2 Published Figures

5 References

View all (55) LRP1 (CD91) antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Published Figures (2)

Application

FIGURE: 1 / 2

LRP1 Antibody (MA1-27198) in Flow

Oncoimmunology 2016 - Figure 4. Human DCs take up platinum-treated tumor cells in a CRT-dependent manner. ( A ) Percentage of uptake of 15 uM OXP or CDDP treated-BLM cells by CD1c + DCs. Control or treated tumor cells were co-cultured with DCs in the presence of isotype (white bar), CRT blocking peptide (gray bar) or irrelevant tumor antigen (gp100) peptide (black bar) for 2 h. Extent of uptake was assessed by flow cytometry. Da... View More

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Product Details

MA1-27198

Applications

Tested Dilution

Publications

Western Blot (WB)

1-5 µg/mL

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1-10 µg/mL

Immunohistochemistry (Frozen) (IHC (F))

1-10 µg/mL

Flow Cytometry (Flow)

Assay-dependent

View 1 publication 1 publication

Neutralization (Neu)

View 2 publications 2 publications

In vitro Assay (IV)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

8G1

Immunogen

Human LRP/alpha2 MR.

Conjugate

Unconjugated

Form

Liquid

Concentration

2.0 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_794778

Product Specific Information

Perform Western blot analysis under non-reducing conditions.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

CD91 is a 600 kDa type I transmembrane protein composed of an alpha and beta chain. The alpha chain interacts with a variety of structurally and functionally diverse ligands, while the beta chain contains two tyrosine phosphorylation motifs that interact with adaptor and signaling proteins. This receptor is expressed by cells in the monocytic lineage, dendritic cells, hepatocytes, fibroblasts, adipocytes, neurons, and syncytiotrophoblasts. CD91 plays a crucial role in several cellular processes, including ligand endocytosis and trafficking to lysosomes, intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. It is involved in cross-presenting antigens via MHC class I molecules on antigen-presenting cells after endocytosis of heat shock protein-peptide complexes. Additionally, CD91 is essential for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of CD91 decreases with age and is found to be lower in brain tissue from Alzheimer patients compared to controls. The receptor also plays a role in cell migration and activating signaling cascades, highlighting its importance in both immune function and disease processes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Proteolytic regulation of a galectin-3/Lrp1 axis controls osteoclast-mediated bone resorption.

The Journal of cell biology

Zhu L,Tang Y,Li XY,Kerk SA,Lyssiotis CA,Sun X,Wang Z,Cho JS,Ma J,Weiss SJ

MA1-27198 was used in In vitro Assay to identify a previously unrecognized galectin-3/Lrp1 axis whose proteolytic regulation controls both the transcriptional programs and the intracellular signaling cascades critical to mouse as well as human osteoclast function.

Mon Apr 03 00:00:00 UTC 2023

Givinostat-Liposomes: Anti-Tumor Effect on 2D and 3D Glioblastoma Models and Pharmacokinetics.

Cancers

Taiarol L,Bigogno C,Sesana S,Kravicz M,Viale F,Pozzi E,Monza L,Carozzi VA,Meregalli C,Valtorta S,Moresco RM,Koch M,Barbugian F,Russo L,Dondio G,Steinkühler C,Re F

MA1-27198 was used in Western Blotting to provide the proof of concept for a delivery system that can improve the in vivo half-life and increase the brain delivery of Givinostat, a pan-HDAC inhibitor.

Thu Jun 16 00:00:00 UTC 2022

Midkine activation of CD8⁺ T cells establishes a neuron-immune-cancer axis responsible for low-grade glioma growth.

Nature communications

Guo X,Pan Y,Xiong M,Sanapala S,Anastasaki C,Cobb O,Dahiya S,Gutmann DH

Published figure using LRP1 monoclonal antibody (Product # MA1-27198) in Neutralization

Fri May 01 00:00:00 UTC 2020

Midkine activation of CD8⁺ T cells establishes a neuron-immune-cancer axis responsible for low-grade glioma growth.

Nature communications

Guo X,Pan Y,Xiong M,Sanapala S,Anastasaki C,Cobb O,Dahiya S,Gutmann DH

Published figure using LRP1 monoclonal antibody (Product # MA1-27198) in Neutralization

Fri May 01 00:00:00 UTC 2020

Human CD1c(+) DCs are critical cellular mediators of immune responses induced by immunogenic cell death.

Oncoimmunology

Di Blasio S,Wortel IM,van Bladel DA,de Vries LE,Duiveman-de Boer T,Worah K,de Haas N,Buschow SI,de Vries IJ,Figdor CG,Hato SV

Published figure using LRP1 monoclonal antibody (Product # MA1-27198) in Flow Cytometry

Mon Aug 01 00:00:00 UTC 2016

Plasma Low-density Lipoprotein Receptor-related Protein 1 Concentration is not Associated with Human Abdominal Aortic Aneurysm Presence.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

Moxon JV,Behl-Gilhotra R,Morton SK,Krishna SM,Seto SW,Biros E,Nataatmadja M,West M,Walker PJ,Norman PE,Golledge J

MA1-27198 was used in blocking or activating experiment to study the role of low-density lipoprotein receptor-related protein 1 in abdominal aortic aneurysm

Thu Oct 01 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: A2MR; Alpha-2-macroglobulin receptor; APOER; Apolipoprotein E receptor; CD91; FLJ16451; low density lipoprotein receptor-related protein 1; LRP-1; MGC88725; Prolow-density lipoprotein receptor-related protein 1; TbetaR-V/LRP-1/IGFBP-3 receptor; type V tgf-beta receptor

Gene Aliases: A2MR; APOER; APR; CD91; IGFBP3R; LRP; LRP1; LRP1A; TGFBR5

UniProt ID: (Human) Q07954

Entrez Gene ID: (Human) 4035

Function(s)

protease binding receptor activity low-density lipoprotein receptor activity calcium ion binding protein binding protein complex binding apolipoprotein binding lipoprotein transporter activity poly(A) RNA binding lipoprotein particle receptor binding apolipoprotein extracellular matrix structural protein transmembrane signal receptor

Process(es)

retinoid metabolic process receptor-mediated endocytosis protein kinase C-activating G-protein coupled receptor signaling pathway aging cell proliferation positive regulation of cholesterol efflux negative regulation of neuron projection development negative regulation of smooth muscle cell migration cerebral cortex development negative regulation of Wnt signaling pathway positive regulation of lipid transport regulation of cholesterol transport regulation of phospholipase A2 activity regulation of actin cytoskeleton organization aorta morphogenesis lipoprotein metabolic process lipoprotein transport apoptotic cell clearance negative regulation of neuron apoptotic process positive regulation of protein transport beta-amyloid clearance negative regulation of platelet-derived growth factor receptor-beta signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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LRP1 Monoclonal Antibody (8G1)

LRP1 Antibody (MA1-27198) in Flow

Product Details

MA1-27198

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (Frozen) (IHC (F))

Flow Cytometry (Flow)

Neutralization (Neu)

In vitro Assay (IV)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Function(s)

Process(es)

Performance Guarantee

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