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LRP2 Antibody (PA5-67900) in IHC (P)
Immunohistochemical analysis of LRP2 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with LRP2 Polyclonal Antibody (Product # PA5-67900) at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chrom... View More
Product Details
PA5-67900
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from human LRP2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
affinity chromatography
Storage buffer
0.42% potassium phosphate, pH 7.3, with 30% glycerol, 0.87% NaCl
Contains
0.01% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2691779
Product Specific Information
Predicted to react with Mouse and Rat samples.
Target Information
The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: calcium sensor protein; Glycoprotein 330; gp330; Heymann nephritis antigen homolog; low density lipoprotein receptor-related protein 2; low density lipoprotein-related protein 2; Low-density lipoprotein receptor-related protein 2; LRP-2; Megalin
Gene Aliases: AI315343; AW536255; b2b1625.2Clo; D230004K18Rik; DBS; GP330; LRP2; Megalin
UniProt ID: (Human) P98164, (Rat) P98158, (Mouse) A2ARV4
Entrez Gene ID: (Human) 4036, (Rat) 29216, (Mouse) 14725
low-density lipoprotein receptor activity
calcium ion binding
protein binding
SH3 domain binding
lipoprotein transporter activity
receptor activity
PDZ domain binding
hemoglobin binding
protein complex binding
low-density lipoprotein particle receptor binding
Wnt-protein binding
Wnt-activated receptor activity
metal ion binding
transmembrane signal receptor
retinoid metabolic process
ventricular septum development
protein glycosylation
lipid metabolic process
endocytosis
receptor-mediated endocytosis
cell proliferation
forebrain development
aorta development
vitamin D metabolic process
lipoprotein transport
coronary vasculature development
vitamin metabolic process
aging
response to X-ray
negative regulation of endopeptidase activity
endosomal transport
hemoglobin import
organ regeneration
response to retinoic acid
response to vitamin D
response to drug
transcytosis
hormone secretion
Wnt signaling pathway involved in dorsal/ventral axis specification
canonical Wnt signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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