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Application
FIGURE: 1 / 4
LRP4 (Extracellular) Antibody (75-221) in IHC (F)
Representative images of EDL muscles of 3 M, 12 M, and 24 M-old mice, whole mount stained with 555-anti-LRP4 (Cat no 75-221, 1:200, red) and NF/Syn (blue). Arrowheads, non-annulospiral axons had no LRP4 expression. Arrows, LRP4 negative annulospiral endings in aged mice. Scale bar, 10 µm. Image from publication CC-BY-4.0. PMID:36765071.
Product Details
75-221
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rabbit,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
N207/27
Immunogen
Fusion protein amino acids 26-350 (extracellular N-terminus) of mouse LRP4 (accession number Q8VI56) produced recombinantly in E. Coli.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4
Contains
0.065% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
This gene encodes a member of the low-density lipoprotein receptor-related protein family. The encoded protein may be a regulator of Wnt signaling. Mutations in this gene are associated with Cenani-Lenz syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Corin; LDLR; LDLR dan; low density lipoprotein receptor-related protein 4; Low-density lipoprotein receptor-related protein 4; LRP-4; Multiple epidermal growth factor-like domains 7
Gene Aliases: 6430526J12Rik; CLSS; CMS17; D230026E03; KIAA0816; LRP-4; LRP10; LRP4; mdig; MEGF7; SOST2
UniProt ID: (Human) O75096, (Mouse) Q8VI56
Entrez Gene ID: (Human) 4038, (Rabbit) 100346254, (Rat) 83469, (Mouse) 228357
kidney development
hair follicle development
endocytosis
dorsal/ventral pattern formation
proximal/distal pattern formation
Wnt signaling pathway
negative regulation of ossification
BMP signaling pathway
odontogenesis of dentin-containing tooth
embryonic digit morphogenesis
dendrite morphogenesis
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of axonogenesis
synapse organization
synaptic growth at neuromuscular junction
protein heterotetramerization
limb development
skeletal muscle acetylcholine-gated channel clustering
negative regulation of canonical Wnt signaling pathway
postsynaptic membrane assembly
presynaptic membrane assembly
positive regulation of presynaptic membrane organization
positive regulation of skeletal muscle acetylcholine-gated channel clustering
regulation of protein phosphorylation
protein localization
negative regulation of Wnt signaling pathway
embryonic limb morphogenesis
receptor clustering
anatomical structure development
multicellular organism development
cell differentiation
Wnt signaling pathway involved in dorsal/ventral axis specification
canonical Wnt signaling pathway
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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