Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
This LRRC8D antibody does not cross-react with LRRC8A.
Immunogen sequence: LQELHLCHC PAKVEQTAFS FLRDHLRCLH VKFTDVAEIP AWVYLLKNLR ELYLIGNLNS ENNKMIGLES LRELRHLKIL HVKSNLTKVP SNITDVAPHL TKLVIHNDGT KLLVLNSLKK MMNVAELELQ NCELERIPHA IFSLSNLQEL DLKSNNIRTI EEIISFQHLK RLTCLKLWHN KIVTIPPSIT HVKNLESLYF SNNKLESLPV AVFSLQKLRC LDVSYNNISM IPIEIGLLQN LQHLHITGNK VDILPKQLFK CIKLRTLNLG QNCITSLPEK VGQLSQLTQL ELKGNCLDRL PAQLGQCRML KKSGLVVEDH LFDTLPLEVK EALNQDINIP FANGI (515-858 aa encoded by BC024159)
Component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8D constitutes a pore-forming subunit or whether it is closely associated with the pore.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HsLRRC8D; leucine rich repeat containing 5; leucine rich repeat containing 8 family; leucine rich repeat containing 8 family, member D; leucine rich repeat containing 8D; leucine-rich repeat containing 8 family member D; leucine-rich repeat-containing 5; Leucine-rich repeat-containing protein 5; Leucine-rich repeat-containing protein 8D; Volume-regulated anion channel subunit LRRC8D
Gene Aliases: 2810473G09Rik; 4930525N13Rik; A930019F03; LRRC5; LRRC8D; UNQ213/PRO239
UniProt ID: (Human) Q7L1W4, (Mouse) Q8BGR2, (Rat) Q5U308
Entrez Gene ID: (Human) 55144, (Mouse) 231549, (Rat) 305131
Molecular Function:
scaffold/adaptor protein
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support