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Invitrogen
LRRN1 Polyclonal Antibody
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Application
FIGURE: 1 / 1
LRRN1 Antibody (PA5-47684) in IHC (F)
Immunohistochemical analysis of LRRN1 in immersion fixed frozen sections of embryonic mouse somites (E9.5). Samples were incubated in LRRN1 polyclonal antibody (Product # PA5-47684) using a dilution of 10 µg/mL overnight at 4 °C followed by NorthernLights™ 557-conjugated Anti-Sheep IgG Secondary Antibody (red) and counterstained with DAPI (blue).
Product Details
PA5-47684
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant human LRRN1 Ser26-Ala631
Conjugate
Unconjugated
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2607190
Product Specific Information
In direct ELISAs and Western blots, approximately 5% cross-reactivity with recombinant human NLRR-3 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Leucine-rich repeat neuronal 1 (LRRN1) is a gene located on chromosome 3q23, which encodes a transmembrane protein belonging to the leucine-rich repeat (LRR) family. This protein plays a significant role in neural development and synaptic plasticity due to its involvement in cell-cell adhesion and signaling pathways. LRRN1 has been implicated in brain development processes, especially in synapse organization and neuronal differentiation. Its expression is primarily localized to the central nervous system, indicating its importance in neurodevelopmental functions. Research has highlighted LRRN1's potential involvement in cognitive functions, and alterations in its expression have been associated with various neurological disorders. Additionally, LRRN1 is thought to contribute to the establishment of neuronal networks by modulating interactions between neurons through extracellular matrix components. Current studies are exploring its contributions to neuropathological conditions, providing insights into its relevance in brain health and disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: fibronectin type III, immunoglobulin and leucine rich repeat domains 3; Leucine-rich repeat neuronal protein 1; LRN; Neuronal leucine-rich repeat protein 1; NLRR-1
Gene Aliases: 2810047E21Rik; FIGLER3; KIAA1497; LRRN1; Nbla10449; NLRR-1; UNQ693/PRO1338
UniProt ID: (Human) Q6UXK5, (Mouse) Q61809
Entrez Gene ID: (Human) 57633, (Mouse) 16979
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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