Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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Recommended positive controls: 293T, HepG2, mouse brain.
Predicted reactivity: Human (98%), Mouse (95%), Rat (94%), Chicken (90%), Sheep (95%), Chimpanzee (98%), Bovine (95%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
LYK5; STE20-related Adaptor Protein (STRAD); FLJ90524. Gene Map Locus is 17q23.3 and members of STE-20 like kinase family are known to stimulate MAPK pathways by directly activating MAPKKK. STRAD is a novel pseudokinase member of this family consisting of a STE-20 like kinase domain but lacks several residues that are required for its catalytic activity. It specifically binds LKB1 and plays a key role in regulating tumor suppressor activities of LKB1. It functions as an upstream activator of LKB1 and also directs the sub-cellular localization of LKB1 by anchoring it in the cytoplasm. STRAD-LKB1 interaction results in phosphorylation of STRAD and enhanced autophosphorylation of LKB1.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: protein kinase LYK5; Serologically defined breast cancer antigen NY-BR-96; STE20-like pseudokinase; STE20-related adapter protein; STE20-related kinase adapter protein alpha; STRAD alpha
Gene Aliases: 2610019A05Rik; 6030402H20Rik; AI480680; E130112C09Rik; LYK5; NY-BR-96; PMSE; Stlk; STRAD; STRADA
UniProt ID: (Human) Q7RTN6, (Mouse) Q3UUJ4
Entrez Gene ID: (Human) 92335, (Mouse) 72149
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