Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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Immunogen sequence: ELVALRVALR EARATLRVSE GRARGLQEAA RARELELEAC SQELQRHRQE AEQLREKAGQ LDAEAAGLRE PPVPPATADP FLLAESDEAK VQRAAAGVGG SLRAQVERLR VELQRERRRG EEQRDSFEGE RLAWQAEKEQ VIRYQKQLQH NYIQMYRRNR QLEQELQQLS LELEARELAD LGLAEQAPCI CLEEITATEI; Positive Samples: DU145, HT-29, HeLa, U-87MG, MCF7, Mouse brain, Rat kidney, Rat brain; Cellular Location: Cytoplasm, centrosome, cytoskeleton, microtubule organizing center
LZTS2 is a negative regulator of katanin-mediated microtubule severing and release from the centrosome. LZTS2 is required for central spindle formation and the completion of cytokinesis.
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Protein Aliases: hLZTS2; Leucine zipper putative tumor suppressor 2; leucine zipper putative tumor suppressor 2 {ECO:0000255|HAMAP-Rule:MF_03026}; leucine zipper, putative tumor suppressor 2; Protein LAPSER1; putative tumor suppressor LAPSER1; RP11-108L7.8
Gene Aliases: BC014695; KIAA1813; LAPSER1; LZTS2; mKIAA1813
UniProt ID: (Human) Q9BRK4, (Mouse) Q91YU6, (Rat) Q3LUD4
Entrez Gene ID: (Human) 84445, (Mouse) 226154, (Rat) 365468
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