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Invitrogen
Lamin C Polyclonal Antibody
Advanced Verification
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
Product Details
PA1-5827
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A peptide made from the last 8 amino acids of lamin C, including an N-terminal lysine as a linker (KHHVSGSRR), coupled to KLH
Conjugate
Form
Liquid
Storage conditions
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Shipping conditions
Wet ice
RRID
AB_1076409
Product Specific Information
PA1-5827 detects Lamin C in human, rat and mouse samples.
PA1-5827 has been successfully used in immunofluorescence, Western blot and immunohistochemistry procedures. PA1-5827 reacts strongly in immunoblotting with fragments corresponding to peptide 319-572aa of Lamin C. When tested against nuclear protein extracts from HeLa cells it reacts with a single band migrating at 65 kDa.
The PA1-5827 immunogen is a synthetic peptide corresponding to the N-terminal residues K-HHVSGSRR of human lamin C, coupled to KLH.
Target Information
Lamin C is intermediate filament protein localized to the inner nuclear membrane. It is expressed predominantly in terminally differentiated cells and defines the shape and stability of nuclei in mammalian cells. Besides their structural roles, lamin proteins also regulate fundamental aspects of nuclear function and they cross-talk with cell signaling cascades and cell metabolism. Mutations of LMNA gene, encoding lamin A and C proteins, are often associated with pathogenesis of respective cell types, such as of heart myocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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