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Invitrogen
Laminin alpha-5 Monoclonal Antibody (CL3118)
Advanced Verification
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
Product Details
MA5-24649
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
CL3118
Immunogen
Recombinant protein corresponding to Human Laminin alpha-5
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2637264
Product Specific Information
Immunogen sequence: LNLSSIILDV NQDRLTQRAI EASNAYSRIL QAVQAAEDAA GQALQQADHT WATVVRQGLV DRAQQLLANS TALEEAMLQE QQRLGLVWAA L
Binds to an epitope located within the peptide sequence RQGLVDRAQQ as determined by overlapping synthetic peptides.
Target Information
Components of the extracellular matrix exert myriad effects on tissues throughout the body. In particular, the laminins, a family of heterotrimeric extracellular glycoproteins, affect tissue development and integrity in such diverse organs as the kidney, lung, skin, and nervous system. It is thought that laminins mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins function as heterotrimeric complexes of alpha, beta, and gamma chains, with each chain type representing a different subfamily of proteins. The protein encoded by this gene belongs to the alpha subfamily of laminin chains and is a major component of basement membranes. Two transcript variants encoding different isoforms have been found for this gene, but the full-length nature of one of them has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: laminin alpha-5 chain; Laminin subunit alpha-5; Laminin-10 subunit alpha; Laminin-11 subunit alpha; Laminin-15 subunit alpha; RP11-157P1.6
Gene Aliases: KIAA0533; KIAA1907; LAMA5
UniProt ID: (Human) O15230
Entrez Gene ID: (Human) 3911
angiogenesis
branching involved in ureteric bud morphogenesis
morphogenesis of a polarized epithelium
neural crest cell migration
hair follicle development
cytoskeleton organization
integrin-mediated signaling pathway
muscle organ development
cell recognition
cell proliferation
embryo development
morphogenesis of embryonic epithelium
cell migration
cell differentiation
regulation of cell adhesion
extracellular matrix organization
lung development
regulation of cell migration
substrate adhesion-dependent cell spreading
regulation of cell proliferation
cilium assembly
odontogenesis of dentin-containing tooth
endothelial cell differentiation
regulation of embryonic development
focal adhesion assembly
branching involved in salivary gland morphogenesis
establishment of protein localization to plasma membrane
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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